It’s a regrettable reality that there is never enough time to cover all the interesting scientific stories we come across. So every month, we highlight a handful of the best stories that nearly slipped through the cracks. October’s list includes an epigenetic mechanism for why large dogs age faster than smaller ones; physicists who trapped a single particle of antimatter for months; and invisible tattoo inks that only show up under UV light.

Why large dogs age faster

In many mammalian species, larger creatures tend to have longer lifespans. Mice, for instance, live an average of just two years, while some whales can last for as long as 200 years. Dogs, however, buck this pattern; larger dogs tend to age faster and die younger than smaller ones, which makes canines an ideal model for biologists to study to learn more about aging in general. Arizona State University scientists report that these lifespan differences seem to be due to so-called "jumping genes," according to a paper published in the journal Science.

The authors used data from 864 dogs collected in the Dog Aging Project to map patterns of DNA methylation (which influences how much certain genes are turned on or off) across the entire genome. It's part of the epigenome, whose markers can change over time in response to stress and other environmental factors. Genetic sequences, by contrast, are largely fixed. So DNA methylation is a good chemical indicator of aging and DNA regulation.

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It's widely acknowledged that it's nearly impossible to publish negative results in scientific journals. "We didn't see anything" is a much harder sell than finding that a hypothesis is clearly right. Findings of no effect tend to either be shuffled off to low-profile journals or left behind as unpublished lab lore.

The high-profile journal Nature, however, made a notable exception this week, publishing a study that tells us that a bunch of methods we have been using to try to measure a key emotional ability don't seem to be measuring the same thing. The results mean that we don't have a good way to measure the impact of a concept that is the basis of a key method in therapy.

Inconsistencies

One of the most successful forms of therapy is cognitive behavioral therapy, or CBT. In part, CBT is based on getting people to step back and engage in "cognitive reappraisal." This requires people to think over a situation that has caused a negative emotional response and find ways to reinterpret it so that it has less impact on them. The ability to engage in this process has been linked to emotional resilience.

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Flying across several time zones often causes jet lag, a feeling where the body insists it's the middle of the night while the clock says it's lunchtime. Now it turns out this nuisance is not exclusive to humans.

A new Science study on Manx shearwaters, seabirds that can fly hundreds of kilometers a day over the North Atlantic, shows they jet-lag themselves during their excursions. And because these birds navigate by the Sun, that jet lag leaves a measurable mark—it skews their compass.

Clockwork compass

Patrick Lewin is a behavioral and sensory ecologist at the University of Oxford and lead author of the study. “Manx shearwaters are medium-sized birds, about the same size as a pigeon,” Lewin said. “They are white underneath and black on top, but they have very long wings, and they are closely related to albatross.” Manx shearwaters nest in burrows on coastal islands around the North Atlantic. Most breed around the UK and Ireland, with about half of their population living in Wales.

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Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down to the positions of specific amino acids, as well as the water molecules that also occupy the area where catalysis takes place. Once you specify these, the tools can build the rest of a protein around this target.

A large collaboration of researchers based in China, however, decided to bring protein design to the masses, making a tool that can take natural language prompts and use them to produce proteins with the function you specify. If your measure for success is a working protein, then the success rate may not be great. But they still manage to get the job done. And, in a separate announcement, Hugging Face shared that it's now hosting a tool that does similar things on the DNA level.

The equivalent of vibe coding may have come to protein design—at least if you have access to a lab where you can sort the good designs from the dozens of failed ones.

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Much of what we know about how a brain makes decisions comes from studying monkeys watching dots. In a task known as a random-dot-motion task, a cloud of flickering specks drifts weakly in one direction while the subject tries to determine whether—and in which direction— it’s moving. The task has shown that in the primate neocortex, neurons gather visual evidence over time, with their firing rates climbing until they cross a threshold, when the animal commits to a decision.

But avian brains don’t have a neocortex, so it wasn’t obvious how they made similar decisions.

“This was the big question,” said Andreas Nieder, a neurobiologist at the University of Tübingen. “How [would] a differently organized avian brain encode decisions?”

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